In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide
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چکیده
منابع مشابه
In vivo Evaluation of Self Emulsifying Drug Delivery System for Oral Delivery of Nevirapine
Nevirapine is a highly lipophilic and water insoluble non-nucleoside reverse transcriptase inhibitor used for the treatment of HIV-1 infection. Lymphoid tissue constitutes the major reservoir of HIV virus and infected cells in HIV-infected patients. Self-emulsifying drug delivery system, using long chain triglycerides, is a popular carrier of drugs due to their ability to transport lipophilic d...
متن کاملSelf-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review
More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...
متن کاملSelf-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development
Volume 5 • Issue 3 • 1000130 J Adv Chem Eng ISSN: 2090-4568 ACE an open access journal Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development Beatriz Zanchetta1,2, Marco Vinícius Chaud3 and Maria Helena Andrade Santana1,* 1Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, SP, Brazil 2Department of Research and ...
متن کاملDesign and Evaluation of Self-Emulsifying Drug Delivery System (SEDDS) Of Carvedilol to Improve the Oral Absorption
BACKGROUND Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs. OBJECTIVES This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system...
متن کاملFormulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure.
The aim of the study was to develop and evaluate a self--emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary ph...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2018
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.03.018